Diabetes with Ketone Bodies in Dogs

Diabetes Mellitus with Ketoacidosis in Dogs

Diabetes is a medical condition in which the body cannot absorb sufficient glucose, thus causing a rise the blood sugar levels. The term “ketoacidosis,” meanwhile, refers to a condition in which levels of acid abnormally increased in the blood due to presence of “ketone bodies”. In diabetes with ketoacidosis, ketoacidosis immediately follows diabetes. It should be considered a dire emergency, one in which immediate treatment is required to save the life of the animal.

This condition typically affects older dogs as well as females. In addition, miniature poodles and dachshunds are predisposed to diabetes with ketoacidosis.

 

Symptoms and Types

  • Vomiting
  • Weakness
  • Lethargy
  • Depression
  • Lack of appetite (anorexia)
  • Weight loss (cachexia)
  • Muscle wasting
  • Increased thirst (polydipsia)
  • Increased urination (polyuria) or lack of thirst (adipsia)
  • Rough hair coat
  • Rapid breathing (tachypnea)
  • Dehydration
  • Low body temperature (hypothermia)
  • Dandruff
  • Sweet breath odor
  • Yellowing of the skin, gums and eyes (jaundice)

Causes

Although the ketoacidosis is ultimately brought on by the dog’s insulin dependency due to diabetes mellitus, underlying factors include stress, surgery, and infections of the skin, respiratory, and urinary tract systems. Concurrent diseases such as heart failure, kidney failure, asthma, cancer may also lead to this type of condition.
 

Diagnosis

You will need to give a thorough history of your dog’s health, including the onset and nature of the symptoms, to your veterinarian. He or she will then perform a complete physical examination, as well as a biochemistry profile and complete blood count (CBC). The most consistent finding in patients with diabetes is higher than normal levels of glucose in the blood. If infection is present, white blood cell count will also high. Other findings may include: high liver enzymes, high blood cholesterol levels, accumulation in the blood of nitrogenous waste products (urea) that are usually excreted in the urine (azotemia), low sodium levels in the blood (hyponatremia), low levels of potassium in the blood (hypokalemia), and low levels of phosphorous in the blood (hypophosphatemia).

Further testing may be required to definitely diagnosis concurrent disease/conditions. For example, urinalysis may reveal abnormally high levels of glucose in urine (glucosuria) and ketone bodies (ketonuria).

polyuria

Excessive urination

polydipsia

A medical condition involving excessive thirst

prognosis

The prediction of a disease’s outcome in advance

urea

The product of protein being metabolized; can be found in blood or urine.

urinalysis

An in-depth examination of the properties of urine; used to determine the presence or absence of illness

ketonuria

A medical condition in which the products of the metabolism of fat is found in the urine

tachypnea

The term for a quick heartbeat

ketone

The product of metabolism of fat; may also be referred to as bodies of ketone or ketone bodies

hypokalemia

Lower levels of potassium in the blood than normal

azotemia

The condition of having urea and other nitrogenous elements in an animal’s blood.

hypothermia

A body temperature that is too low

insulin

A hormone created by the pancreas that helps to regulate the flow of glucose

jaundice

A condition in which the skin becomes yellow in color as do the mucous membranes; this is due to excess amounts of bilirubin.

asthma

An allergic disorder that results in difficulty breathing.

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