Metabolic Muscle Disease without Inflammation in Cats

Non-inflammatory Metabolic Myopathy in Cats

Non-inflammatory metabolic myopathy is a rare muscle disease associated with metabolic disorders like various enzyme defects or storage of abnormal metabolic byproducts and others. Unfortunately, little is known about how the disorder affects cats exactly.

Symptoms and Types

  • Muscular weakness
  • Cramps
  • Exercise intolerance
  • Regurgitation and/or difficulty swallowing (dysphagia)
  • Collapse
  • Dark urine
  • Vomiting
  • Abdominal distention


  • Congenital (born with this problem) error in metabolism
  • Acquired (later in life) problems in metabolism
  • Viral infections
  • Drug exposure
  • Environmental factors


You will need to give a thorough history of your cat’s health, the onset and nature of the symptoms, to your veterinarian. He or she will then conduct a complete physical examination as well as a biochemistry profile, urinalysis, and complete blood count — the results of which may show abnormalities related to metabolic problems involved. For example, the biochemistry profile may show abnormal levels of serum creatine (enzyme found in muscle, brain, and other tissues) and abnormally low levels of glucose (hypoglycemia).

Your veterinarian may also choose more enzyme assays and other specific testing to determine the cat’s levels of amino acids, organic acids, and creatine. DNA-based tests, meanwhile, are used to identify specific carriers.

Often, a muscle tissue sample will be sent to a veterinary pathologist for further evaluation. This may reveal abnormal accumulation of fats or glycogen within muscle cells.


A condition of the muscles in which they are diseased


The prediction of a disease’s outcome in advance


An in-depth examination of the properties of urine; used to determine the presence or absence of illness


A substance that causes chemical change to another


The process of making something larger by dilating or stretching it


Condition in which eating and/or swallowing is difficult

amino acids

Organic substances that aid in the creation of proteins; also the end product of the decomposition of certain proteins.


Low amounts of glucose in the blood

Leave a Reply