Non-inflammatory Myopathy of Endocrine Origin in Dogs

This form of non-inflammatory myopathy is a type of muscle disease caused by endocrine maladies such as hypo- and hyperthyroidism. However, non-inflammatory myopathy of endocrine origin has also been associated with corticosteroid use.

Symptoms and Types

  • Muscle weakness
  • Loss of muscle bulk
  • Stiffness
  • Cramps
  • Regurgitation
  • Difficulty in swallowing (dysphagia)
  • Hoarseness (dysphonia)


Ultimately, this type of non-inflammatory myopathy is due to an endocrine disorder — such as hyperadrenocorticism, hypothyroidism, or hyperthyroidism — but may be immune-mediated or neoplastic in nature.


You will need to give a thorough history of your dog’s health, including the onset and nature of the symptoms, to the veterinarian. He or she will then conduct a complete physical examination as well as a biochemistry profile, urinalysis, and complete blood count (CBC) to determine the type of endocrine disorder. Your veterinarian will also conduct thyroid and adrenal gland functions tests to confirm the diagnosis.

X-rays are conducted to evaluate pharyngeal and esophageal functions — especially in patients with regurgitation and dysphagia — while muscle samples are sent to veterinary pathologist for further evaluation.


The return of food into the oral cavity after it has been swallowed


An in-depth examination of the properties of urine; used to determine the presence or absence of illness


The prediction of a disease’s outcome in advance


A condition of the muscles in which they are diseased


Condition in which eating and/or swallowing is difficult

adrenal gland

The gland that produces the hormone adrenaline and others; helps to regulate the metabolism, electrolytes, and even sexual function; also helps to regulate the way the body responds to injury, trauma, etc. The adrenal gland is found near the kidney. Also referred to as the suprarenal gland.

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